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KMID : 0620920190510020016
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Experimental & Molecular Medicine
2019 Volume.51 No. 2 p.16 ~ p.16
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High-resolution respirometry in human endomyocardial biopsies shows reduced ventricular oxidative capacity related to heart failure
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Scheiber Daniel
Jelenik Tomas
Zweck Elric
Horn Patrick
Schultheiss Heinz-Peter
Lassner Dirk
Boeken Udo
Saeed Diyar
Kelm Malte
Roden Michael
Westenfeld Ralf
Szendroedi Julia
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Abstract
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The lifetime risk of developing heart failure is approximately 20%, and survival rates remain poor. Myocardial mitochondrial function has been suggested to play a pivotal role in heart failure pathophysiology. Human studies on ex vivo mitochondrial function have mostly been limited to atrial tissue obtained during open heart surgery and have provided contradictory results. This study aimed at measuring myocardial mitochondrial function in transcatheter ventricular endomyocardial biopsies and assessing the relationship between oxidative capacity and heart function. We enrolled 40 heart failure patients undergoing ventricular assist device surgery or heart transplantation (34 males, age 57?±?11 years, body mass index 26.6?±?4.8?kg/m2) and 29 heart transplant recipients of comparable age and body mass index with normal left ventricular function undergoing surveillance biopsies (23 males, 57?±?12 years, body mass index 26.2?±?4.1?kg/m2). High-resolution respirometry was established in the myocardium to measure oxidative capacity ex vivo. The mitochondrial oxidative capacity was 90% higher in ventricular compared to atrial tissues (n?=?11, p?
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KEYWORD
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Energy metabolism, Heart failure
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